Probability Models for Biomolecular Motifs
Human genetics and bioinformatics, areas of science
made prominent by the successful completion of the human genome project, will
play increasingly important roles in biomedical science over the next 100
years. These disciplines depend on the development of novel methods of
statistical analysis, and were the background to the annual Moyal Lecture at
Macquarie University on 31 October.
Terry Speed, Professor of Statistics at the
University of California at Berkeley for half of each year, and Head of the
Division of Bioinformatics at the Walter and Eliza Hall Institute for the
remaining half, discussed a key topic in bioinformatics in this public lecture.
Professor of Statistics at the University of
California at Berkeley for half of each year, and Head of the Division of
Bioinformatics at the Walter and Eliza Hall Institute for the remaining half,
Terry Speed, explained these and other possibilities in this public lecture.
"In this lecture I will review more than a decade's
research on applying certain stochastic models to biological sequence analysis
and show how they provide an important tool for discovering certain domains,
called motifs, in different sequence segments", Professor Speed said.
Professor Speed is the world's expert on the
statistical analysis of microarray data. These data (taken from an entire
genome) are the most important genetic data currently being analysed.
Macquarie University's Deputy Vice-Chancellor
(Research), Professor Jim Piper, presented Professor Speed with the 2003 Moyal
Medal for his contribution to statistical methodology and statistical genetics.
He has written more than 150 journal papers covering algebra, probability
theory, applied and theoretical statistics, and statistical genetics.
The annual Moyal Lecture honours the late Professor
José Enrique Moyal, one of Australia's most remarkable scientists and former
professor of mathematics at the Australian National University and Macquarie
University. Moyal's insights into the interaction between mathematics, physics
and statistics led him to make contributions to these subjects which have had
far-reaching ramifications in all three fields.
His wife, Ann, a distinguished historian of
science, made the seed donation to Macquarie to set up the annual Moyal lecture
and medal. Many of Professor Moyal's past colleagues and students have
contributed to the fund.
The lecture series aims to influence and interest
graduates and postgraduate students, as well as to provide a meeting ground for
researchers in these disciplines from universities in the region.
Associate Professor John Corbett
Department of Mathematics